| Draft Selection | Draft Source | Position | Player | Age | SI | Pot | Assignment | Team | Statistics | |
|---|---|---|---|---|---|---|---|---|---|---|
| 2064, Rd #2 | Junior College | C | Johnny Hayes | 19 | 87 | 15 | Rookie | League City Indians | ||
| 2064, Rd #1 | High School | P | Sammie Roberts | 17 | 35 | 12 | Rookie | League City Indians | ||
| 2063, Rd #4 | International | P | Kyle May | 21 | 34 → 39 | 11 | - | - | ||
| 2063, Rd #3 | High School | P | Quentin Daly | 18 | 41 → 44 | 11 | Rookie | League City Indians | ||
| 2063, Rd #2 | College | 3B | Jimmy Kimball | 21 | 68 → 73 | 12 | AA | League City Indians | ||
| 2063, Rd #1 | Latin American Academy | 2B | Raúl Amaya | 22 | 91 → 95 | 13 | AAA | League City Indians | G 8, AVE .500, H 1, SB 3 | |
| 2062, Rd #8 | Junior College | C | Don Morris | 20 | 68 | 11 → 10 | - | - | ||
| 2062, Rd #6 | College | C | Grady Schrock | 23 | 62 | 10 | - | - | ||
| 2062, Rd #5 | College | OF | Billy Ray Myers | 22 | 65 → 74 | 11 | AAA | League City Indians | ||
| 2062, Rd #4 | Latin American Academy | 2B | Abelardo Briones | 20 | 77 → 90 | 12 | AAA | League City Indians | ||
| 2062, Rd #3 | Latin American Academy | 2B | Ernesto De León | 19 | 53 → 65 | 13 → 12 | A | League City Indians | ||
| 2062, Rd #2 | Latin American Academy | P | Rueben Loera | 18 | 42 → 50 | 13 | Rookie | League City Indians | ||
| 2062, Rd #1 | College | P | Kip Powers | 23 | 52 → 59 | 14 → 13 | AA | League City Indians | ||
| 2061, Rd #6 | Latin American Academy | P | Bernardo Román | 21 | 46 → 51 | 11 | A | League City Indians | ||
| 2061, Rd #5 | Latin American Academy | OF | Christian Villa | 22 | 54 → 65 | 11 | - | - | ||
| 2061, Rd #4 | Latin American Academy | OF | Carlos Escobedo | 19 | 66 → 74 | 10 → 11 | A | League City Indians | ||
| 2061, Rd #3 | Junior College | OF | Benito Aguirre | 22 | 83 → 96 | 12 | AAA | League City Indians | G 8, AVE .167, H 2 | |
| 2061, Rd #2 | Asian Posting System | 3B | Jin Hoon Kim | 27 | 78 → 83 | 14 | - | - | ||
| 2061, Rd #1 | Latin American Academy | P | Juan Pablo Pantoja | 22 | 52 → 76 | 11 → 12 | Majors | League City Indians | G 3, W 1, L 0, ERA 15.43, IP 2⅓, K 1 | |
| 2060, Rd #5 | High School | 1B | Damian McGhee | 21 | 57 | 11 → 10 | - | - | ||
| 2060, Rd #4 | Junior College | OF | Jesus Fierro | 23 | 83 → 98 | 11 → 12 | Majors | League City Indians | G 75, AVE .235, H 28, HR 3, R 15, RBI 17 | |
| 2059, Rd #3 | Junior College | P | Billy Ray Straus | 24 | 34 → 69 | 12 | AAA | League City Indians | ||
| 2059, Rd #2 | College | OF | Dillon Hutchinson | 25 | 68 → 86 | 12 | AAA | League City Indians | ||
| 2059, Rd #1 | Junior College | P | Oscar Carrillo | 23 | 54 → 89 | 14 | AA | League City Indians | G 47, W 6, L 4, ERA 4.98, IP 97⅔, K 64 | |
| 2058, Rd #3 | College | 2B | Ernie Reece | 27 | 84 → 114 | 14 | AAA | League City Indians | G 272, AVE .197, H 154, HR 9, R 108, RBI 70, SB 80 | |